Saints Vs 49ers 2025. Williams (knee) got hurt in the first half. The saints / 49ers rivalry has been played 79 times (including 1 postseason game), with the new orleans saints winning 27 games and the san francisco 49ers winning 50 games.
5:30 pm (cst) halftime performer: Games and scores from the 49ers 2025 regular, pre and post season schedules